The second-largest city in Portugal was nominated European City of Culture for 2001 and the historical center is a UNESCO World Heritage Site. Founded by the Romans at the mouth of the River Douro, modern Porto (Oporto) is an industrial city with a wonderful atmosphere and plenty to see. The sights of the old town include the Cathedral (Sé), dating from the 12th to the 18th centuries, the Church of São Francisco, famous for its rococo interior, a splendid example of Portuguese gilt-work (talha dourada), the 19th century Stock Exchange and the Torre Dos Clérigos, which offers wonderful views. The old waterfront, known as the Cais da Ribeira (a World Heritage Site), caters for tourists with cafes, restaurants and an open-air market. Across the river, the 18th century Port wine lodges of Vila Nova de Gaia are open to the public for tours and tastings.